How to translate clinical trial results into gain in healthy life expectancy for individual patients

How to translate clinical trial results into gain in healthy life expectancy for individual patients.

1 1Department of Vascular Medicine, University Medical Centre Utrecht, PO Box 85500, 3508 GA Utrecht, Netherlands 2Harvard Medical School, Boston, MA, USA; Centre for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA 3Julius Centre for Health Sciences and...

How within-city socioeconomic disparities affect life expectancy? Results of Urban HEART in Tehran, Iran

  Background :There is substantial lack of knowledge about the role of socioeconomic status (SES) indicators on life expectancy (LE) within-cities, especially within mega-cities. We aimed to investigate the disparities of LE within city districts of Tehran, Iran, and specify how SES inequalities play role on LE.   Methods : The death and population data for 2010 by different age, gender, and re...

Why clinical trial outcomes fail to translate into benefits for patients

Clinical research should ultimately improve patient care. For this to be possible, trials must evaluate outcomes that genuinely reflect real-world settings and concerns. However, many trials continue to measure and report outcomes that fall short of this clear requirement. We highlight problems with trial outcomes that make evidence difficult or impossible to interpret and that undermine the tr...

Methods for life expectancy and healthy life expectancy uncertainty analysis

Healthy Life Expectancy Is Expanding.

This is a very complex issue given that the issue involves many factors, including genetics, socioeconomic status, culture, and the quality and availability of healthcare services. Furthermore, it is not easy to define many of the above elements (e.g., culture, quality). Even if we could, determining the individual effects of components that we know can influence healthy life expectancy (HLE) (...